Endocrine Abstracts

Background: Pituitary adenoma (PA) is an under-investigated pathology in the elderly.Objective: To review our case records of patients >70 years with PA, in order to evaluate presentation symptoms, hormonal results, and pituitary morphology.Patients: 48 patients aged 70 years or older (21 females/27 males) were identified from the group of 610 patients with PA (7.9%) diagnosed at Neuroendocrine Unit, Clinic for Endocrinology, B...

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

Patients with hypopitutarism have higher cardiovascular morbidity and mortality rates than general population, as manifested by elevated fasting lipids and insulin resistance. The aim of our study was to evaluate the lipid levels and insulin responses during oral glucose tolerance test (OGTT) in adult onset growth hormone deficiency (AO-GHD), without growth hormone replacement during a follow-up period of seven years. Ten hypopituitary patients with operated non-functioning pi...

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

Introduction: Pregnancy and lactation-associated osteoporosis (PLO) is a rare condition in which women have fragile fractures associated with significant reduction of BMD during pregnancy or postpartum period.Case report: A 37-year-old female patient was admitted at our Clinic for further investigation of aetiology of osteoporosis in July 2019. Soon after delivery in February 2019 patient had felt left hip and foot pain as well as sharp intensive pain (i...

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

Spontaneous subarahnoid hemorrhage (SAH) is a recently identified risk factor for hipopituitarism, especially growth hormone (GH) and corticotroph deficiencies. The aim of this study is to perform the initial screening procedure to identify the patients with increased risk of neuroendocrine dysfunction after SAH in the chronic phase and to identify the possible predictor(s) for neuroendocrine dysfunction. Ninety-one patients (30 males, 61 females), age between 19 and 69 years ...

Introduction: The most common etiology of endogenous Cushing’s syndrome (CS) is Cushing’s disease (CD). Patients with CS also represent a model of patients with metabolic syndrome (MetS) with associated increased cardiovascular morbidity and mortality. Insulin resistance and obesity, two major characteristics of CS, lead to the accumulation of triglycerides within hepatocytes and formation of fatty liver in these patients.Aim: To evaluate the p...

Introduction: Xanthomatous hypophysitis (XH) is characterized by inflammatory infiltration of the pituitary gland in which lipid laden macrophages predominate. It can be primary (3% of all primary hypophysitis) and secondary arising in the setting of other lesions: craniopharyngioma, Rathke’s cleft cyst (RCC), adenomas (with subclinical apoplexy). It is more common in women and younger people. The clinical presentation is similar to pituitary tumors and may prese...

Introduction: Structural and functional damage of the skeletal system resulting in fractures is a common complication of CD. Due to major effect of glucocorticoids on the trabecular bone, vertebral fractures are a common and severe complication which can lead to disability.Goal: To investigate the prevalence of skeletal complications (osteoporosis, osteopenia, presence of fragility fractures) in patients with Cushing’s disease, as well as gain insig...